Therapy for the Coronavirus, COVID-19 Pandemic

ABSTRACT

The present invention provides methods of treating a coronavirus, COVID-19 disease. COVID-19 disease is caused by the coronavirus, SARS-COV-2. 
     Treatment of the SARS-COV-2 infection could be achieved by administering a single element or a combination of elements in the protocol of therapies comprising of
         1) A laxative   2) A Nutritious Meal followed by a cup of green tea, raw honey, lemon. milk and a dessert of pear d&#39;anjou and strawberries   3) Administering drugs and vitamins. These drugs could be anti-parasitic, antiviral, antibacterial and/or immunomodulatory.   4) Providing for the subject infected with the SARS-COV-2 to enjoy the treat of a plain water hot bathtub bath. Some Epsom Salt should be added to the plain water hot bathtub bath. The subject should be encouraged to spend at least 30 minutes in the hot bathtub bath.   5) A Physical Exercise session.
           6 Claims, 0 Drawing Sheets.

BACKGROUND The COVID-19 Disease: An Overview

COVID-19 is the code name given by World Health Organization (WHO) to aninfectious disease outbreak in Wuhan, Hubei province, China. Theoutbreak occurred in December 2019. COVID-19 stands for Corona Virus2019. The coronavirus, SARS-CoV-2, causes the COVID-19 disease [1, 2, 3,4, 12].

SARS-CoV-2 stands for Severe Acute Respiratory Syndrome Coronavirus Type2.

SARS-CoV-2 has hemagglutinin, a glycoprotein, with which it binds tocells. SARS-CoV-2 gains entry into a cell through theangiotensin-converting enzyme II (ACE2) receptor [2].

The symptoms of COVID-19 disease include fever, dry cough, fatigue, lossof taste or smell, nasal congestion, conjunctivitis, sore throat,headache, muscle or joint pain, different types of skin rash, nausea orvomiting, diarrhea, chills or dizziness, shortness of breath, loss ofappetite, confusion, persistent pain or pressure in the chest, hightemperature (above 38 degrees Celsius), irritability, sepsis, reducedconsciousness, anxiety, depression, sleep disorders, alveolar damage,strokes, brain inflammation, delirium, nerve damage, breathing failureand death [2, 4, 11, 12].

ACE2 receptor is implicated as the entry port for the SARS-CoV-2 intothe cell, and some of the cells expressing ACE2 receptors include:

-   -   I. Type II Aveolar cells (AT2) of the lung    -   II. Esophagus upper    -   III. Stratified epithelial cells    -   IV. Absorptive enterocytes from ileum and colon    -   V. Cholangiocytes    -   VI. Myocardial cells    -   VII. Myoctes    -   VIII. Vascular endothelial cells    -   IX. Kidney proximal tubule cells    -   X. Bladder urothelial cells [2, 4].

Organs having cells with a “high expression of ACE2 receptor”, presentspotential candidates for infection of the SARS-CoV-2 [2, 11].

About 80% of subjects infected with the coronavirus, COVID-19 disease donot require treatment as their innate immune system is sufficient tofight off the viral infection. The level and quality of antibodies in asubject is essential in the fight against the SARS-CoV-2 infection [5].Obviously, about 20% of those infected with COVID-19 disease may requiretreatment.

At the onset of the SARS-CoV-2 infection, macrophages are deployed tocombat the infection. If the fight between the macrophages and thecoronavirus, SARS-CoV-2 does not last long enough, and the macrophagesare overwhelmed by SARS-CoV-2, T-Cells are recruited prematurely toengage in the fight; sometimes, this creates an out-of-control andsevere inflammatory reactions of cytokines. This over reaction ofcytokines is classified as “cytokine storm” and in some cases, it hasfatal consequences.

SARS-CoV-2 possesses a weapon or tool, the hemagglutinin which issuspected in causing blood clotting in some infected subjects. It isalso suspected that SARS-CoV-2 degrades collagen in infected subjects.Collagen is vital for gene regulation, cellular signals, celldifferentiation and metabolism. The gradual degradation of collagen bySARS-CoV-2 manifests as symptoms of COVID-19 disease. Further researchand clinical trials may be needed to determine and confirm thesesuspicions.

Classification of Coronavirus, Covid-19 Patients

-   -   I. Mild—likely to recover from patient's immune system plus        aspirin    -   II. Moderate—patient has fever and some symptoms of chest/lung        congestion    -   III. Severe—patient has fever, congestion in the lung but less        likely to die    -   IV. Critical—patient has fever, ARDS, SARS and could be on a        ventilator or intubated. Patient is more likely to die.    -   ARDS—Acute Respiratory Distress Syndrome    -   SARS—Severe Acute Respiratory Disease

DETAILED DESCRIPTION OF THE INVENTION

This invention will treat an infection of the coronavirus, COVID-19disease by disrupting the lipid bilayer membrane of SARS-CoV-2 anddisrupting the viral assembly of progenies.

The invention provides a method of treating the coronavirus, SARS-COV-2,COVID-19 disease in an infected subject comprising of some protocols andactivities. Through extensive research, this invention is borne as adiscovery of the potentials of some amino acids and elements that couldbe enhanced, exploited and administered as a therapy for theCoronavirus, COVID-19 Pandemic. Some of these amino acids and elementsinclude—tryptophan, gluconic acid, proline and propolis.

The drugs and vitamins stated in the invention constitute the activeingredients or agents; these active ingredients combined with someactivities, is propose as a treatment for an infection of theSARS-CoV-2, COVID-19 disease. This invention would cause significantdistress upon the lipid bilayer membrane of SARS-CoV-2; denaturing thecoronavirus, SARS-CoV-2 and potentially triggering apoptosis of thecoronavirus, SARS-CoV-2. This invention is expected to boost the immuneand cardiovascular systems of the subject. The invention creates amicroenvironment that is hostile to the coronavirus, SARS-COV-2 but safeto the infected subject (human or non-human).

To gain the optimum benefits of this invention, the first three claimsof the invention (claim 1, claim 2 and claim 3), should be administeredin their entirety to a subject infected with the SARS-CoV-2, COVID-19disease. The proposed optimum benefits notwithstanding, each claim maybe administered alone or in combination with other claims of thisinvention or beyond this invention.

Concepts of virology and molecular biology were applied in theconception of this invention to treat an infection of the coronavirus,SARS-CoV-2 in a subject (human or non-human) [13].

Laxative

The invention starts with administering a laxative to the subjectinfected with the COVID-19 disease. The laxative comprises of CastorOil, Epsom Salt, Polyethelene glycol or Docusate sodium for enema(rectal). Administering Castor Oil, Epsom Salt, Polyethelene glycol orDocusate for enema (rectal) to a subject provides a scenario synonymousto deploying “soap” into and through the alimentary canal of thesubject. The coronavirus has a fragile lipid bilayer membrane.Interactions of the laxative with the SARS-CoV-2 during cell metabolismwould strip off or distress the fragile lipid bilayer of thecoronavirus. The laxative would cause the bowels of the subject to bepurged; causing the excretion of some level of the viral load and toxinsfrom the infected subject.

Sources of Amino Acids and other Elements in the Invention

A healthy meal is essential for boosting the immune system of thesubject infected with COVID-19 disease. This is obvious, and thisinvention utilizes nutrients such as amino acid as sources of energy toboost the immune system and fight off the infection of the coronavirus,COVID-19 disease.

A nutritious meal comprising of salmon, turkey, cheese or a vegetariandelight, combined with a drink of green tea, raw honey, lemon, milk, andfollowed by a dessert of pear d'anjou and strawberries, will provideamino acids and elements vital to treating the SARS-CoV-2, COVID-19disease. Some essential elements comprising of flavonols, gluconic acid,tryptophan, propolis and some measure of hydrogen peroxide formed duringglycolysis constitutes nutrients and elements that would enable thedisruption of the lipid bilayer of SARS-CoV-2 as well as boost theimmune system of the subject.

-   -   Gluconic acid is obtained from raw honey and pear d'anjou.        During glycolysis when the enzyme, glucose oxidase reacts with        glucose, gluconic acid as well as hydrogen peroxide is formed        [6, 14]. Some process of producing gluconic acid utilizes        nitrogen and phosphorus [14]. The lipid bilayer of the        coronavirus, SARS-CoV-2, has phosphorus at the ends. The E        protein of SARS-CoV-2 has a negatively charge N-terminal. With        the nutrients that this invention provides, during glycolysis,        the phosphorus on the coronavirus presents as a reactant in cell        metabolism; producing gluconic acid and hydrogen peroxide. The        gluconic acid acidifies the microenvironment with a pH of about        4.5-6.0; the production of hydrogen peroxide creates a chain        reaction in which hydrogen electrons from the lipid bilayer of        SARS-CoV-2 are “stolen” in the chain reactions with the hydrogen        peroxide radicals to form water. Such a reaction termed lipid        peroxidation would denature the SARS-CoV-2. This is of vital        importance as the reaction disrupts both (i) the fragile lipid        bilayer of SARS-CoV-2 and (ii) the viral assembly of progenies.        This will induce apoptosis of SARS-CoV-2.    -   Tryptophan is an amino acid that could be obtained from a        nutritious meal comprising of salmon, turkey, chicken and milk.        Tryptophan is vital for nitrogen balance and the creation of        niacin. Niacin is vital in the production of serotonin, a        neurotransmitter. Additional health benefits include the        nourishing of the circadian rhythm; leading to balanced sleep,        relief from depression and better pain management.    -   Proline is an amino acid that is obtained from raw honey [6].        Proline nourishes the muscles of the heart, joints and tendons.    -   Propolis is another element that offers immense health benefits        such as nourishing and providing a balanced concentration of        collagen. Propolis is obtained from raw honey.

Drugs (the Active Agents) for Treating the COVID-19 Pandemic

-   -   The drugs pyrimethamine offer benefits to infected subjects who        are immunocompromised. Sulfadoxine is lipid soluble and        penetrates the lungs in significant concentration.    -   Montelukast sodium. Motelukast sodium is a leukotriene receptor        antagonist that blocks the LTD4 receptor; offering relief to a        congested lung by decreasing the inflammation of the lungs and        causing the relaxation of smooth muscle.    -   Rosuvastatin is used to lower the risk of stroke and heart        attack given that it works to reduce high levels of cholesterol        and triglyceride levels.    -   Vitamins C, Vitamin B and Vitamin D supplements. Vitamin D        regulates the concentration of calcium in the blood while        Vitamin C is for the growth and repair of tissues. Vitamin B        nourishes the energy levels, activities of the brain and general        metabolism of cells.

Hot Bathtub Bath

A hot bathtub bath saturated with Epsom salt and some body wash or gelshould be included in the treatment regimen of the subject infected withSARS-CoV-2, COVID-19 disease. The subject should submerge in thebathtub. While submerged, the subject should have their eyes open. Thiswould expose the conjunctiva to the benefits of the hot bathtub bath.The subject should spend at least 30 minutes in the hot bathtub bath. Aperson skilled in Epigenetics understands how this activity assists intoning and reducing the risk of inflammation in a subject.

The skin is the largest organ of the body and ACE2 receptors areextensively expressed on the skin. The hot bathtub bath offers thehealth benefits comprising of:

-   -   An assistance in the proper functioning of the cardiovascular        system    -   The relief of congested lungs through the opening of alveoli    -   The cerebrospinal fluid is heated, soothed and energized;        resulting in a lowered risk of any incidence of syringomyelia    -   An improved action potentials and a balanced composition of        trace elements in the brain which will result in a reduced        incidence of intracranial pressure (ICP). The incidence of ICP        is termed “brain fog” or delirium and presents as one of several        neurological symptoms of the COVID-19 disease [7, 8, 9, 11, 15].        This issue with ICP lingers on with some of the patients who        have recovered from the COVID-19 disease. These patients are        termed “long haulers”.    -   Reducing the risk of inflammation throughout the neurological        and biochemical systems of the subject infected with the        COVID-19 disease.

Physical Exercise

Physical exercise sessions would assist in improving the flow of fluidsin the circulatory system as well as assist in muscle, joints andtendons development and restoration. Some of the physical exercisesrecommended for the subject infected with the COVID-19 disease comprisesof:

-   -   Undertake a significant distance walk    -   Ride an exercise bike    -   Exercise on a treadmill    -   Swim vigorously or partake in some vigorous exercise.

SUMMARY

A person skilled in the art of clinical health services understands thatthis invention offers treatment of the SARS-CoV-2, COVID-19 Pandemic tothe outpatient community, primarily. Millions of subjects are infectedwith the COVID-19 disease and the hospitals are overwhelmed withCOVID-19 cases. This invention would assist tremendously in treatingsubjects infected with the Coronavirus, SARS-CoV-2 in an outpatient aswell as inpatient setting.

Subjects infected with the COVID-19 disease fall into one of fourcategories—Mild, Moderate, Severe or Critical. The severity of thedisease increases from Mild →Moderate →Severe →Critical. As the severityof the disease increases in a patient, the patient degenerates and somehundreds of thousands of patients have died from the SARS-CoV-2infection, unfortunately. This invention offers the potentials foroutpatient treatment of subjects (persons) who tested positive for theinfection of SARS-CoV-2.

Subjects infected with COVID-19 disease that are at the early stages ofthe disease progression (Mild to Moderate stages), could self-managetheir recovery from the COVID-19 disease in an outpatient setting usingthis invention as the therapy for coronavirus, COVID-19 disease. Thisinvention would treat the COVID-19 disease for infected subjects in theSevere to Critical categories, also.

This invention would also treat the cases of patients who have recoveredfrom an infection of the COVID-19 disease but are experiencing theissues of “brain fog”. Subjects in this category are termed “longhaulers”. This invention would provide rehabilitation and restoration toa “new-normal-health” for these subjects who have recovered from aninfection of the COVID-19 disease but yet burdened by the “long hauler”syndrome.

The elements within a claim may be administered entirely, partially orin combination thereof as the condition of the infected subject maypermit.

The optimum potentials of this invention as a therapy for COVID-19disease would be harnessed for the full benefit of an infected patientwhen claims 1, 2 and 3 are administered to a subject, completely.

REFERENCES/BIBLIOGRAPHY

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5. Ed Yong. Immunology Is Where Intuition Goes to Die.www.theatlantic.com. [Online] Aug. 5, 2020. [Cited: Aug. 9, 2020.]www.theatlantic.com/health/archive/2020/08/covid19-immunity-is-the-pandemics-central-mystery/614956/.

6. Bruna Costa Ferreira da Cruz, Ludmilla Ronqui, et. al. HealthBenefits of Honey. www.intechopen.com. [Online] Jul. 23, 2019. [Cited:Sep. 13, 2020.]www.intechopen.com/books/honey-analysis-new-advances-and-challenges/health-benefits-of-honey.DOI: 10.5772/intechopen.88211.

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1. Administering some laxative comprising of (a) the Castor Oil (RicinusOil), (b) Epsom Salt, or (c) Polyethelene glycol mixed in a cup of greentea, raw honey, lemon and milk followed by a pear d'anjou and somestrawberries. Those skilled in the art of clinical health servicesunderstand that when laxatives are administered, a lapse of time isexercised in wait.
 2. Administering some drugs (the active agents)comprising of: Pyrimethamine Sulfadoxine Rosuvastatin calcium Aleukotriene receptor antagonist such as Montelukast SodiumAcetylsalicylic acid Vitamin C Vitamin D (preferably, vitamin D₂ orvitamin D₃) Vitamin B (preferably, vitamin B₁₂ or vitamin B₃) 3.Providing a treat of a hot bathtub bath saturated with Epsom Salt forthe subject infected with the coronavirus, SARS-COV-2, COVID-19 diseaseto submerge into. The bath may be scented with some aromatic scents toentice the subject to partake in the exercise. The subject should spendabout 30 minutes in the hot bathtub bath.
 4. A treatment of thecoronavirus, COVID-19 disease wherein claim 1 is combined with claim 2and combined with claim
 3. 5. A treatment of coronavirus, COVID-19disease wherein claim 1 is combined with claim
 2. 6. A treatment ofcoronavirus, COVID-19 disease wherein claim 2 is combined with claim 3.